The Rodent In Vivo Assessment Core (RIVA) specializes in the design and conduct of rodent models based on behavior and genetics and includes 40+ models to identify therapeutic targets and disease modifying genes, test mechanistic hypotheses, and perform in vivo compound screens. The RIVA core has the capability to conduct a wide array of in vivo assays in mice and rats, ranging from general health assessments and simple screening assays (e.g., open fields, light-dark exploration) to more sophisticated assays (e.g., Pavlovian and Instrumental conditioning, Morris water maze, self-administration, drug discrimination). Efforts are ongoing to build further strengths in assessment of adsorption, disposition, metabolism and excretion in rodents to allow safety testing of potential therapeutic compounds. The RIVA Core also contains its own facility for the housing and care of animals operated under the direction of the AAALAC-accredited UTMB Animal Care Facility. Director: In transition

The Cellular and Molecular Signaling Core provides state-of-the-art equipment for various biochemical analyses of cellular signaling cascades. The objective of this core is to maximize therapeutic advances by tying clinical observations to parallel cellular and molecular biology knowledge. It is equipped for a wide range of medium-throughput plate assay analyses of neuronal signaling cascades in support of both neuromechanistic and drug discovery efforts. This facility operates 24/7, and provides training, protocols, and assistance to facilitate new discoveries in substance use disorders and brain health research Director: Noelle Anastasio, Ph.D.

The Pilot Research and Grant Development Core is Dedicated to enhancing UTMB’s research efforts focused on addiction and related mechanisms. This core supports the development of new investigators, promotes scientific collaborations among established researchers, and encourages creativity through high-risk pilot projects. Each year, CAST supports up to three innovative research projects for predoctoral and postdoctoral mentees and junior faculty. Director: Kathryn Cunningham, Ph.D.

Molecular Therapeutics Core facilitates the transition from discovery of small molecule therapeutics through validation to their eventual out-licensing or commercialization for substance use disorders and related disorders. This resource provides researchers unique tools for development of their early-stage discoveries by offering collaborations with chemists interested in conducting translational research. Director: Christina Merritt, Ph.D.