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Faculty Profile

Taglialatela, Giulio, PhD
Taglialatela, Giulio, PhD

Professor

Lawrence J. Del Papa Distinguished Chair in Neurodegenerative Disease Research
Professor and Vice President and Research Institute Director of the UTMB Brain Health Institute (BHI)

Department: Neurology

Bio ,  Curriculum Vitae
UTMB Health Research Expert Profile

 PubMed

    • 1984: M.S. Biology (Neuroendocrinology), University of Rome “La Sapienza”, Rome, Italy
    • 1988: Ph.D Neuropharmacology, University of Rome “La Sapienza”, Rome, Italy
    • 1990: Postdoc, Dept. of Human Biological Chemistry & Genetics (currently Biochemistry & Molecular Biology), UTMB Galveston, Texas
    • Molecular mechanisms of neurodegeneration and cognitive decline in Alzheimer Disease and related disorders
    • (from 85 peer-reviewed publications)Karlnoski R, Wilcock D, Dickey C, Ronan V, Gordon MN, Zhang WR, Morgan D, Taglialatela G (2007): Up-Regulation of Bcl-2 in APP Transgenic Mice is Functionally Neuroprotective, Neurobiol Dis, 25(1):179-88; E-pub ahead of print October 25, 2006.
    • Dineley K, Hogan D, Zhang W, Taglialatela G (2007): Acute inhibition of calcineurin restores associative learning and memory in Tg2576 APP transgenic mice. Neurobiol Learn Mem. 88(2):217-224.
    • Reese LC, Zhang W, Dineley KT, Kayed R, Taglialatela G (2008): Selective induction of calcineurin activity and signaling by amyloid beta oligomers. Aging Cell, 7:824-835.
    • Taglialatela G, Hogan D, Zhang W, Dineley K (2009): Intermediate and long-term recognition memory deficits in Tg2576 mice are reversed with acute calcineurin inhibition. Behav Brain Res, 200(1):95-9.
    • Vascotto C, Cesaratto L, Zeef LA, Deganuto M, D’Ambrosio C, Scaloni A, Romanello M, Damante G, Taglialatela G, Delneri D, Kelley MR, Mitra S, Quadrifoglio F, Tell G (2009): Genome-wide analysis of proteomic studies reveal APE/Ref-1 multifunctional role in mammalian cells. Proteomics 9(4):1058-74.
    • Dineley K, Kayed R, Neugebauer V, Yu F, Zhang W, Reese L, Taglialatela G (2010): Calcineurin mediates memory deficits induced by Intracerebral injection of amyloid beta oligomers in mice. J Neurosci Res, 88(13):2923-32.
    • McNearney TA, Ma Y, Chen Y, Taglialatela G, Yin H, Zhang WR, Westlund KN (2010): A peripheral neuroimmune link: glutamate agonists upregulate NMDA NR1 receptor mRNA and protein, vimentin, TNF-alpha, and RANTES in cultured human synoviocytes. Am J Physiol Regul Integr Comp Physiol. 298(3):R584-98.
    • Mukherjee A, Morales R, Gonzales D, Green K, Taglialatela G, Soto C (2010): Calcineurin Inhibition at the Clinical Phase of Prion Disease Decreases Neurodegeneration Leading to Clinical Improvement and Increase of Animal Survival. PLoS Pathogens, 6(10):1-12.
    • Reese L and Taglialatela G (2010): Neuroimmunomodulation by calcineurin in aging and Alzheimer Disease. (Invited review) Aging and Disease, 2010.
    • Dineley KT, Kayed R, Neugebauer V, Fu Y, Zhang W, Reese LC, Taglialatela G (2010): Amyloid-beta oligomers impair fear conditioned memory in a calcineurin-dependent fashion in mice. J Neurosci Res. Oct;88(13):2923-32.
    • Reese LC, Laezza F, Woltjer R, Taglialatela G (2011): Dysregulated phosphorylation of Ca++/Calmudulin-dependent protein kinase IIa in the hippocampus of subjects with mild cognitive impairment and Alzheimer’s disease. J Neurochem, 119(4)791-804
    • Reese L and Taglialatela G (2011):  A role for calcineurin in Alzheimer’s Disease. (Invited review) Curr Neuropharm, 9(4):685-92.
    • Crawford J, Taglialatela G, Bjorklund N, Gomer R (2012): Brain Serum amyloid P levels are reduced in individuals that lack dementia while having Alzheimer's disease neuropathology. Neurochem Res, 37(4):795-801.
    • Bjorklund NL, Sadagoparamanujam VM, Taglialatela G (2012): Selective, quantitative measurement of releasable synaptic zinc in human autopsy hippocampal brain tissue from Alzheimer’s disease patients. Neurosci Methods, 2012, 203(1):146-151
    • Mantha A., Dhiman M., Tagliatatela G, Perez-Polo R, Mitra S (2012): Proteomic Study of Amyloid Beta (25-35) Peptide Exposure to Neuronal Cells: Impact on APE1/Ref-1’s Protein-Protein Interaction. J Neurosci Res, 90(6):1230-9
    • Martin ZS, Neugebauer V, Dineley KT, Kayed R, Zhang W, Reese LC, Taglialatela G (2012): Alpha synuclein oligomers oppose long term potentiation and impair memory through a calcineurin-dependent mechanism: relevance to human synucleopathic diseases. J Neurochem, 120(3):440-52.
    • Bjorklund NL, Reese LC, Sadagoparamanujam VM, Ghirardi V, Woltjer RL, Taglialatela G (2012): Absence of amyloid beta oligomers at postsynapse and regulated synaptic zinc in cognitively intact aged individuals with Alzheimer’s disease neuropathology. Mol Neurodegener  7(1):23.
    • Stoica G, Lungu G, Bjorklund NL, Taglialatela G, Zhang X, Chiu V, Hill HH, Schenk JO, Murray I. (2012): Potential role of alpha synuclein in Neurodegeneration: Studies in a rat animal model. J Neurochem, 122(4):812-22.
    • Sallam HS, Tuvdendorj D, Tumurbaatar B, Zhang W, Taglialatela G, Nicola Abate (2014): Peripheral adipose tissue insulin resistance alters lipid composition of CNS hippocampal synapses. J Neurosci Res, submitted.
    • Bjorklund NL, Ghirardi V, Zhang W, Taglialatela G (2014). Sustained hippocampal neurogenesis in non demented individuals with Alzheimer neuropathology. In preparation.
    • Bjorklund NL, Sadagoparamanujam VM, Cicalese P, Taglialatela G (2014). Differential metal regulation and preserved metallothionin-3 levels in the CNS of non demented individuals with Alzheimer neuropathology. In preparation.
    • Elected President, Society for Neuroscience Galveston Chapter.
    • Elected Chair, UTMB Faculty Senate (2002)
    • Graduate Program Teaching Excellence Award in Neuroscience (2010)
    • Appointed Mace Bearer, UTMB GSBS Commencement (2012)
    • Appointed Chair, Biophysical, Physiological, Pharmacological and Bioengineering Neuroscience Study Section, NIH.
    • Graduate School Faculty Service Award (2013)
    • Graduate School/GSO Teaching Excellence Award (2013)
    • Graduate Program Teaching Excellence Award in Neuroscience (2014)
    • Society for Neuroscience
    • American Society for Neurochemistry