Midoro - Horiuti, Temuri MD

Terumi Midoro-Horiuti MD
RESEARCH 
Professor

Terumi Midoro-Horiuti MD
Pediatric Health Child Research
 Midoro-Horiuti Laboratory Team
Route: 0366 | Tel: (409) 772-3832 | midoro@utmb.edu

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Research Interests 

A new deep learning approach to probe the molecular basis of inhalation and food allergens.

Mitochondrial DNA damage from allergic disease induces neuroinflammation and inhibits recovery from mild traumatic brain injury.

Educational Opportunities

  • Open for rotation students and
  • Medical school research opportunities

Research Highlights

Recent awards Lab Photo with 4 people including Dr. Midoro Horiuti and Dr. Garafalo

  • Clinical Research Directed Initiative/UTMB Mitochondrial DNA damage from allergic disease induces neuroinflammation and inhibits recovery from mild traumatic brain injury 

  • R01 AI195888 NIH/NIAID A new deep learning approach to probe the molecular basis of inhalation allergens 

  • R21AI193195 NIH/NIAID Novel Artificial Intelligence approaches to distinguish allergenic from non-allergenic proteins 

  • Annual meeting of American Academy of Allery, Asthma, Immunology Travel Award

Publications

  • Sowers, M.L., Tang, H., Tian, B., Goldblum, R., Midoro-Horiuti T., Zhang, K. Bisphenol A activate an innate viral immune response pathway. J Proteome Res, 19:644-654. 2020. PMCID: PMC8311900, Cited: 13 

  • Negi, S., Goldblum, R.M., Braun, W., Midoro-Horiuti, T. Design of peptides with high affinity binding to a monoclonal antibody as a basis for immunotherapy. Peptides, 145:170628-170628. 2021. PMCID: PMC8484066, Cited: 4 

  • Koizumi, K., Kuzume., K, Ishida, Y., Midoro-Horiuti, T. The usefulness of serum thymus and activation-regulated chemokine (TARC/CCL17) as an evaluation tool for atopic dermatitis in infants aged 3-5 months. Allergy, Asthma Proceeding, 43:461-467. 2022. Doi: 10.2500/aap.2022.43.220034, Cited: 5 

  • Midoro-Horiuti, T., Peptide immunotherapy for inhaled allergens. Jon J Pediatr Allergy Clin Immunol, 2022, 36(2), 152-156. 

  • Murakami, Y., Fahmy, S., Goldblum, R.M., Watson, C.S., Midoro- Horiuti, T. Environmental estrogen exposures alter molecular signaling in immune cells that promote the development of childhood asthma. Molecular Immunology 2023, 157, 142-145. Cited: 4 

  • Midoro-Horiuti, T. Schein C.H., Peptide immunotherapy for aeroallergens. Allergy, Asthma Proceeding 2023, 44 (4): 237-243. Cited: 5 

  • Midoro-Horiuti, T., Murakami, Y., Kuzume, K., Toler, R.M., Zhang, K. Maternal exposure to Bisphenol A has transgenerational effects on the development of experimental asthma through bromodomain-containing protein 4/zinc finger DHHC-type containing 1/stimulators of interferon genes axis. International Journal of Environmental Health Research. 2025, 35(10): 3112-3122. PMCID: PMC12353454 

  • Midoro-Horiuti, T., Murakami, Y., Kuzume, K., Toler, R.M., Zhang, K. Transgenerational effects of bisphenol S exposure on the development of experimental asthma. Journal of Environmental Science and Health, Part C. 2025 43(3): 228-242. PMCID: PMC12303729 

  • Mori, Y., Toler, R.M., Mori, S., Truong, N., Horiuchi, S.M., Midoro-Horiuti, T. Effects of environmental estrogen on asthma development of pulmonary inflammation response in murine model of older adults. Journal of Environmental Science and Health, Part C. (in press). 

Presentations

  • Kuzume, K., Y. Murakami, S. Fahmy, R.M. Goldblum, Midoro-Horiuti, T. Bisphenol S (BPS) has Transgenerational Effects on the Development of Experimental Asthma, Annual Meeting of American Academy of Allergy, Asthma and Immunology. February 25-28, 2022 

  • Midoro-Horiuti, T., K. Kuzume, K., R.M. Goldblum, K. Zhang. Bisphenol A (BPA) has transgenerational effects on the development of experimental asthma through BRD4/ZDHHC-1/STING axis. Asthma, Annual Meeting of American Academy of Allergy, Asthma and Immunology. February 24-27, 2023 

  • Midoro-Horiuti, T. Murakami, Y., Fahmy, S, Watson, CS., Goldblum, RM. Multigenerational effects of maternal bisphenol S exposure on the development of experimental asthma. Federation of Clinical Immunology Societies. June 22-26, 2023. 

  • Toler, RM., Murakami, Y., Fahmy, S., Kuzume, K., Watson, C.S., Goldblum, R.M., Midoro-Horiuti, T. The Role of the BRD4/ZDHHC-1/STING Axis on Allergic Asthma Development. GCC 4th Annual Immunology Conference. April 9-10, 2024 

  • Toler, RM., Murakami, Y., Fahmy, S., Kuzume, K., Watson, C.S., Goldblum, R.M., Midoro-Horiuti, T. Effect of environmental estrogen on the development of allergic asthma. The McLaughlin Colloquium. April 12, 2024, received a Travel award 

  • Midoro-Horiuti, T. Murakami, Y., Fahmy, S, Watson, CS., Goldblum, RM. The role of the BRD4/ZDHHC-1/STING axis on allergic asthma development. Federation of Clinical Immunology Societies. June 22-26, 2024. 

  • Toler, R.M., Horiuchi, S.M. Zhang, K., Raji, M., Midoro-Horiuti, T. Effects of Environmental Estrogens on Asthma Development in Older Adults. The 27th Annual Forum on Aging. October 17, 2024 

  • Toler, RM., Murakami, Y., Fahmy, S., Kuzume, K., Watson, C.S., Goldblum, R.M., Midoro-Horiuti, T. Transgenerational effects of early environmental estrogen (EE) exposure on asthma development. Annual Meeting of American Academy of Allergy, Asthma, Immunology March 2025. 

  • Toler, RM., Murakami, Y., Fahmy, S, Watson, CS., Goldblum, RM, Zhang, K., Midoro-Horiuti, T. The role of the BRD4/ZDHHC-1/STING axis on allergic asthma development. Research Day, Galveston, TX, May 29, 2025. 

  • Mori, Y., Okamoto, K., Kondo, T., Mizutani, K., Matsumoto, Y., Nakajima, Y., Midoro-Horiuti, T., Kondo, R., Horiguchi, T., Kondo, Y. Effect of the “Ho Inhalation Method” on Posterior Pharyngeal Wall Area in Children, Galveston, TX, Oct. 15, 2025, received a Travel award 

  • Mori, Y., Okamoto, K., Kondo, T., Mizutani, K., Matsumoto, Y., Nakajima, Y., Midoro-Horiuti, T., Kondo, R., Horiguchi, T., Kondo, Y. Effect of the “Ho Inhalation Method” on Posterior Pharyngeal Wall Area in Children, Orlando, FL, Nov, 2025. Received travel award. 

  • Mori, Y., Toler, R.M., Horiuchi, S.M., Raji, M.,  Midoro-Horiuti, T. Environmental Estrogens Promotes Airway Hyperresponsiveness and Neutrophilic Inflammation in Aged Mice, McLaughlin colloquium, April 17, 2026, Galveston, TX 

  • Truong, N., Mori, Y., Toler, R.M., Nori, S., Horiuchi, S.M., Midoro-Horiuti, T. Estrogens Promotes Airway Hyperresponsiveness and Neutrophilic Inflammation in Aged Mice, Competitive Summer Research Program Poster Session, Sep. 11, 2026, Galveston, TX 

  • Truong, N., Mori, Y., Toler, R.M., Nori, S., Horiuchi, S.M., Midoro-Horiuti, T. Estrogens Promotes Airway Hyperresponsiveness and Neutrophilic Inflammation in Aged Mice, Aging Forum, Oct. 29, 2026, Galveston, TX